Study on semi-bionic extraction of Astragalus polysaccharide and its anti-aging activity in vivo

Astragalus membranaceus ( A. ) is a homologous plant with high medicinal and edible value. Therefore, the extraction methods of polysaccharide (APS) have attracted attention many research groups, but yield active components still not high. The aim this study was to extract APS by semi-bionic method, optimize process, evaluate anti-aging activities in vivo . results showed that 18.23% when extracted method. Anti-aging evaluation rats method significantly decreased malondialdehyde (MDA) content increased superoxide dismutase (SOD) activity cope D-galactose-induced aging. Serum metabolomic analysis indicated total 48 potential biomarkers significant differences, mainly involving 5 metabolic pathways. These altered pathways were related energy metabolism, amino acid lipid metabolism. can effectively improve APS, exhibited rats. Our provided novel effective be used as functional food natural medicine delay aging prevent its complications.